you may have noticed that Abe, and the other mudokons no longer have that kind pocket in the back of their loincloth, where, presumably, abe carry bones, meat, and granades, in the first two games.
The original idea of AO and AE was to have a inventary option, like many other games, but that idea was discarded to make gameplay easier.
Now, in MO, Abe doesnt seem to have where to carry objects. Maybe he wont be able to do that, so that avery time he needs something, like a cup of expresso, he will have to look for and find a expresso vending machine.
About the way Abe dies, it was mentioned that the game will be able to be configured before you start to play it, making the gameplay easier or harder. this way, bullets could hurt like tennis balls(making Abe resist longer shooting sequences) or kill in the first hit.
About the self-healing process, I guess the fleeches example of how that works will be used again. abe can resist a few fleeches attack, then run away. If he got hit before a predetermined numbers of seconds had elapsed, he dies, otherwise, he can resist a few attacks again, and so on.
Maybe Abe just dies, becoming a bunch of birds, or maybe he wont, just getting addicted and arrested, instead. for example: if abe is shot by a big bro slig using blitzpackerz machine gun, the same thing that happened to a wild mudokon being hit by a blitzpacers shooting machine, in one of OWI movies, will happen to Abe. Or maybe abe is imune to that product, and the other, after all, Abe could drink soulstorm brew in AE, withou getting addicted, he just farted explosive farts