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I don't think you can fuck up your blood flow. Unless you have it on so tight that your penis starts going purple.
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Yeah, exactly. Vendors of cock rings and medical sources always indicate that cock rings are not to be worn for more than about 30 minutes. Falling asleep or using illicit drugs at the same time is very dangerous. This may cause priapism, a medical emergency that, if not treated promptly, can result in severe and permanent damage, including penile gangrene that can result in the destruction and possible amputation of the penis.
Got that from Wikipedia.