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I remember playing an excellent Oddworld game that had no Mudokons in it.
It was called Stranger's Wrath.
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I believe Strangers Wrath and Abes Oddysee took place in locations far apart from each other, mainly because there are almost no reoccurring species other than the odd few.
Edit: Yeah AO is in the Eastern Mudos and Strangers Wrath is in Western Mudos.
Source:
http://oddworld.wikia.com/wiki/Mudos