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Thought adding the numbers to the grid according to their coordinates would help.
It didn't help me much, was thinking it might be a Sudoku style grid, but obviously not.
The numbers in red are from the first line of coordinates, the green are the second line, blue from the third line and black from the last.
I assumed coordinate 1,1 would be the top left, even that could be wrong 
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Dont give up, we could be onto something here!
But the way a grill works is that the piece you place over all the letters singles out certain letter that when rearranged make a word.
Sometimes it even has to be rotated apparently.