It matters, as it's just one step further into making game more schematic. See, you can complete main Fallout 1/Fallout 2 quest in more than one way. The game doesn't neccessarily tell you where to go, but you can ask around random people and some will help you pinpoint the possible locations. And you don't even have to visit some, even if they contain the main quest item you seek. There are just a few instances of those in the game. It makes you want to explore more instead of going in straight line to a fucking marker. Also, I don't remember any quest in F3 and F4 that made you go to a place A *or* a place B. Even if it did, that would be pretty pointless, because the player will simply choose the closest location.
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