I spend all the time at the Computer sitting and I do feel the negatives of it all the time. (bad back, I have RSI in my right wrist). You just need to stretch a lot.
But on the other hand, I'm standing up all day at work and need the rest. I'm not coming home and standing up again on the PC.
I think standing desks are cool though. You definitely need to get used to them though. (I don't have on obviously, but I've used one.)
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