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I had a good run with Eden that very rapidly turned into a bad run but I'm not entirely sure why. I started out with the Bible (I assume you always do with an Eden Roll) and high damage+ high tears and two hearts.
I Got Dark Bum, the Friend that spits out blue flies, the wub wub worm, fire tears, the pentagram and Leo, which seems to give you stomping ability if you take damage, all within the first 3 or 4 floors.
I was doing very well until Utero II, where my Dark Bum decided to start spitting out normal red hearts instead of soul hearts. I'm pretty sure either a trinket or a permanent upgrade is to blame but I can't remember which one.
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You dont start with the bible with Eden, everything is random. Even their hairstyle. And leo gives u HP up + Speed down + thundre thighs (right?) If its thunder thigh then u get stomping regardless, u dont need to take damage.