The Thinking Atheist A non-confrontational show, host Seth Andrews has a very approachable, professional, and intimate style, which seems to serve largely as a regular sanity check for other non-believers surviving in the American Bible belt.
Star Talk Radio "bridges the intersection between pop-culture and science". Host Neil deGrasse Tyson (your personal astrophysicist) and occasionally substitute host Bill Nye the Science Guy. Some shows feature an interview with a guest, who may be involved in the sciences or may be a figure of pop culture with a personal interest in it (such as Lawrence Fishburne, GZA, Dan Akroyd and Hank Azaria), other shows feature "Cosmic Queries" in which Neil or a knowledgable guest answer a grab-back of science questions from the audience. Regular co-hosts generally alternate between comedians Eugene Merman and Chuck Nice.