[Phylum]

Cain's Luck Foot is amazing, because you can just eat all of the pills without worrying about anything. Judas is also really powerful if you like making devil deals, if he's anywhere near as powerful as in the original game. I like that they've made him so much harder to unlock now.

Have you guys had any luck with Eden yet? My only run with her so far saw me roll 1 in every stat, when apparently it's supposed to be random?

Also Dark Bum isn't really that great for soul heart generation. He can be powerful if you're lucky, but with battery drops the Book of Revelations is usually better and gives additional bonuses (unless you hate devil rooms and the cube of meat/bandages).