You can have Whore of Babylon active perpetually if you keep Eve at 1 red heart. Soul hearts and shadow hearts don't count, so you want to use items that reduce heart canisters and make devil deals, and then just rely on things like Dark Bum to keep you alive. If you get a good run, you can get ridiculously powerful, because iirc the Whore effect is applied on top of your damage stat - ie if you have max damage you'll still deal twice as much.
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