One of the benefits of using Unity is that it (theoretically) exports seamlessly to several platforms. The differences will all be cosmetic, although the FPS change could effect some things. NTSC versions of certain PS2 games are better for speedrunning than the PAL releases, because certain things move a little bit faster at 60fps rather than 50. I don't know how much power Unity gives to its users about framerate-dependency, but it hopefully won't even be an issue.
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