I think if there isn't some kind of grid system in place we might start to see some messy animation. A lot of things like Abe's jumping and ledge hanging rely on the grid system; if that goes then we'll probably see some "correction" in the animations.
Whether or not that will matter probably comes down to how noticeable it is. You can see a bit of this in action in the original Eurogamer announcement footage - when Abe hoists up onto the first ledge he shuffles back a bit.
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