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I'd disagree with that - as long as you know from the start that you're building a responsive layout you can take steps to keep your workload from getting too large.
Essentially all you're doing is building two layouts using the same base elements - the only difference is that instead of both being separate sets of files they're built together.
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You'd be a lot better off taking the existing themes and just coming up with new images. Much the same way as Native, Honeybee and Industrial are structurally similar.