Once you get into the groove a bit more and actually get a Mom kill you'll be finding more Devil rooms than you know what to do with. They take some of the random away at the price of hearts. Unlocking Judas and Cain is a pretty big deal for faster and more consistent runs, too. Cain especially makes it much easier to blast through the early stages with a tonne of soul hearts. Judas kills everything too quickly to bother with taking damage, plus the low HP makes you learn to dodge boss attacks. They both have good starting speed, too.
DSS is useless. My favourite held item to date is probably the Book of Belail, but that gets less useful as the game goes on and you get up towards full power.
Since figuring out what it did Luck Foot is my favourite thing ever. Pick it up whenever you can.
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