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Original Metal Gear Solid is the best start you can get. Furthermore, MGS2 and MGS4's plots depend heavily on MGS1 storyline
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Plus while MGS3 is set before MGS1, it’s full of references and wink-wink-nudge-nudges that you wouldn’t get without playing MGS1 and 2 first.
I have a status report on Mass Effect – the Mako is fukken
illin’, and now the plot has moved me out into actual missions the game is a bit more enjoyable. However, I’m not happy that the game ganked me immediately after a cutscene and then decided to stick the last autosave aaaallllll the way back at the start of the planet.