As far as I can tell, the only ending where the galaxy is screwed is the 'Bad' Red ending where the citadel laser obliterates ALL LIFE. In the other endings, the reapers die and/or the synthetics die and the Mass Relays break. They don't explode violently like the Batarian one that kills 300,000 of them.
One thing I think most people can agree on, the music on the first mission with the shuttles where Shepard looks at the kid, is one of the best pieces of Mass Effect music.
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