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Aren't all the Cartel's companies in the middle of nowhere? Nobody is meant to venture outside (Especally the Mudokons) That's why they have FeeCo trains going to and from.
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The explanation for Rupturefarms being out in the middle of nowhere was that, in the grand scheme of things, that particular factory was little more than a third world outpost. Molluck was a big shot compared to the rest of the local businesses, but was a small fry in the bigger picture.
I imagine all the industrial buildings in AE are surrounded by desert for similar reasons.