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Soldier.
I'm using the Geth Shield Boost, which pulled me out of the shit a few times. I found Mordin very handy, just got Heavy Incinerate so that'll serve me well.
Miranda's also pretty good, Warp and Overload are a match made in heaven for Eclipse Vanguards and shielded opponents.
On the Collector ship now, a little stuck on the Praetorian. I never realised Harbinger was so god-damned hard on Insanity, he just unleashes a barrage of shit on me.
If I can get Heavy Overload for Garrus, I'll take him with me and Mordin to get Tali, I'm dreading the thought, though.
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Concussive shot is effective against barriers, and the Cain vastly reduces the length of the Praetorian fight.
Fun business with Harbinger, though: if you have Dominate (you get it it you betray Samara and recruit Morinth instead, you need a high Paragon or Renegade score to choose), it's basically AI hacking for organics, then you can turn him against his fellow collectors. You can't dominate him directly, he has no red health bar, but he always possesses the most wounded Collector, so bait one is such a way and use Dominate on him. If you time it right, Harbinger will possess him immediately after and fight for your side.
If not, slide along cover to avoid being knocked out of it by that attack of his, and for god's sake, use Adrenalin Rush at every opportunity. Hardened, preferably, you'll need it when sprinting to a new piece of cover when he gets too close.