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overdo it on marijuana and you can trigger underlying mental issues. we should all know this, but there will always be those who just want to take the piss with how much they want to take.
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While I do certainly agree, I would like to repeat that Pot also fucks up your lungs and voicebox if you don't lock it down (which I didn't). My voice is a bit crinklier now. A bit.
But regardless, it still just makes you either a useless lump or cavorting hooligan. Harmless in moderation, just like everything else. (As you pointed out)