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Total personality change, all grades plummeted, paranoia, inability to concentrate, irritability and confusion. It was scary to watch, the change was overnight. He would disappear for a week at the time on sick leave soon after, and was soon removed from public education altogether for more personal care. This was after a single use.
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There is no point denying that stuff like that can happen after a single use. But the chances of that aren't very high.
We had an interesting discussion about drug use and stuff with a psychologist today =)