I still haven't played Bioshock 2 (although I do love this commercial:
http://www.youtube.com/watch?v=6hzsCV8Ec8Y). The first one was a brilliant masterpiece of a game, though. This looks like it will be another great game, and I am glad to see the series moving away from Rapture and focusing on the mystery of "what the hell happened here?" again.
Definitely looking forward to this... although I could have sworn I already said I was looking forward to this game on this forum...