When I first encountered the pursuit cops in Mirror's Edge. Suddenly the balance of power shifted dramatically.
When I first me my daughter Rosemary in my first play-through of Fable 2. My heart melted.
When I figured out how to and then resurrected my dog in my second play-through of Fable 2.
The speech sequence at the beginning of Gears of War 2. And the times I single handedly beat most of a wave's locusts including all the Maulers and Bloodmounts on several occasions in a game of Horde, saving the day for my two other active allies.
The first time I generated a combined creature in Impossible Creatures, and the first time I generated one that was actually good.
Playing Dawn of War over the LAN at my student house, three of us in a fortress going up against five CPs on Insane difficulty, and just sending our guys to the pass to defend it for hours while we gathered the strength to make coordinated strikes out in the open. It was a low frame-rate massacre, not least because of all the thousands of orks patiently queuing in the huge throng beyond our walls, waiting their turn to meet their deaths at our desperate, overwhelmed hands (and the fact that we also had persistent corpses turned on).
Every single moment of Mass Effect.
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