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I could be off my nut here, but aren't royal family bloodlines known to inbreed? Aren't there stories of royal families having babby after babby until one is 'acceptable' as an heir, due to the genetic difficulties encountered with inbreeding; killing off the hideously deformed ones?
I vaguely recall there being stories like this; royal families believing they were 'cursed' because of all the hideously deformed children.
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King Tut had a long list of medical problems which I think are believed to have come from incest.