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Well, using sense is advisable no matter what you're doing. I'm generally not afraid to try things, but when it comes to "drugs" I did quite a bit of sleuthing to figure out what I was getting into before I tried them.
The only main drawback I could find was an argument that weed was mildly addictive, but after further checking it seemed to be more of a psychological thing. Is it an escape?
OOOH, DRUGS=BAD!
No... ANYTHING is bad in large amounts when it is abused. Cigarettes... water.... off-the-shelf pain killers....
So, Got any weed? 
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I was going to but I thought I would save my money. I know cigarettes aren't
really saving my money but I know Ill want them more.
I doubt salvia is saving money eather
My mum used to eat 'shrooms when we lived in our old flat. Apparently a packet of prawn cocktail crisps was chasing her mate down the stairs.