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Surely there are horrific side-effects?
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I think mentally, your ordinary run-of-the-mill Slig is already mentally scarred and pretty much ruined in that aspect to the point it's not going to get any worse. I'd suspect Big Bros have reduced lifespans due to increased biological activity. I'm certain the worst effects would be mental, and that isn't so much an issue for Sligs which do as ordered anyway. The effect on other Oddworldian species could be vastly different.