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What happens to a zombie if it's heart explodes?
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Zombies can only be killed by destroying the brain. You could chop off the head, but even though the body will just collapse, the head will still snap at you. You'll still have to smash it or toss it in a fire.
That's the brilliance of the Solanum virus. It makes the brain into a completely self-sustaining unit. It only needs the body for mobility and grabbing food.