There are a few probems with your solution to the problems of Oddworld...
1) I dout that the Vykkers have quite prefectect genetic engernearing... Thats why their still always testing things.
2) I don't think that the Mudukons are smart anuff to do it them selfs... Not that they don't have the potental to be smart, it's just that they haven't exacty had a formal education or anything.
3) And the Vykker are to well gaurded to fall to the rath of the Mudukons... After all it takes most of a game for just Abe and Munch to get back on to the Vykkers air ship let alone a army.
Keep the ideas coming...
