Much harder in AO. Once you leave Rupture Farms, killing muds gets really difficult. I gave up at the near the end of the Stock Yards and tried AE.
My current total:
Total Muds: 300
Escapees: 6
Casualties: 211
... uh-oh, Im half way through the brewery now, I hope I can kill enough... all that work for nothing.

How could I have possibly missed so many muds?