You have no limits, no restraints. A player can start a game and abandon the story missions all-together, and just explore the massive, living world. San Andreas is insane, because there is so much to do from the very start.
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No they aren't.
MMORPGs like eve online are more open ended than freaking GTA.
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MMORPG's are for only the most hardcore of gamers, and frankly, the majority are poo anyway. They always seem very stale and non-interactive. The genre has a long way to go.